Montedinove is a comune (municipality) in the Province of Ascoli Piceno in the Italian region Marche, located about 70 kilometres (43 mi) south of Ancona and about 13 kilometres (8 mi) north of Ascoli Piceno. As of 31 December 2004, it had a population of 566 and an area of 11.9 square kilometres (4.6 sq mi).
The municipality of Montedinove contains the frazioni (subdivisions, mainly villages and hamlets) Croce Rossa, Contrada lago, San Tommaso, and Trippanera.
Montedinove borders the following municipalities: Castignano, Montalto delle Marche, Montelparo, Rotella.